Structure of Histone Deacetylases

Histone Deacetylases Inhibit IFN-

Chemical Phylogenetics of Histone Deacetylases

The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived as nonselective. The synthesis and study of ...

Histone Deacetylases and Cardiometabolic Diseases.

Cardiometabolic disease, emerging as a worldwide epidemic, is a combination of metabolic derangements leading to type 2 diabetes mellitus and cardiovascular disease. Genetic and environmental factors are linked through epigenetic mechanisms to the pathogenesis of cardiometabolic disease. Post-translational modifications of histone tails, including acetylation and deacetylation, epigenetically a...

Regulating histone acetyltransferases and deacetylases.

Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with specific transcription factors. In this review...

2-subunit gene: role of histone deacetylases

Zhang, Wenzheng, and Bruce C. Kone. NFB inhibits transcription of the H -K -ATPase 2-subunit gene: role of histone deacetylases. Am J Physiol Renal Physiol 283: F904–F911, 2002. First published July 9, 2002; 10.1152/ ajprenal.00156.2002.—The H -K -ATPase 2 (HK 2) gene plays a central role in potassium homeostasis, yet little is known about its transcriptional control. We recently demonstrated t...